HCID 178447445, compound → HCID 178447441, compound

HRID 2389190Notes

Reaction equation

[N+](C(C1C=CC2C(=CC=C(O[C@H]3CC[C@H](C(F)(F)F)CC3)C=2)C=1)(C)CCC(O)=O)([O-])=O.C[O:33][C:34](=[O:67])[CH2:35][CH2:36][C:37]([N+:64]([O-:66])=[O:65])([C:39]1[CH:48]=[CH:47][C:46]2[C:41](=[CH:42][CH:43]=[C:44]([O:53][C@H:54]3[CH2:59][CH2:58][C@@H:57]([C:60]([F:63])([F:62])[F:61])[CH2:56][CH2:55]3)[C:45]=2[C:49]([F:52])([F:51])[F:50])[CH:40]=1)[CH3:38]>>[N+:64]([C:37]([C:39]1[CH:48]=[CH:47][C:46]2[C:41](=[CH:42][CH:43]=[C:44]([O:53][C@H:54]3[CH2:55][CH2:56][C@@H:57]([C:60]([F:61])([F:62])[F:63])[CH2:58][CH2:59]3)[C:45]=2[C:49]([F:50])([F:51])[F:52])[CH:40]=1)([CH3:38])[CH2:36][CH2:35][C:34]([OH:67])=[O:33])([O-:66])=[O:65]

Participants

Reactant 2

HCID 178447445HCID 178447445, compound

HCID 178500161HCID 178500161, compound

Product 1

HCID 178447441HCID 178447441, compoundYield 93%

Procedure

4-Nitro-4-[5-trifluoromethyl-6-(cis-4-trifluoromethyl-cyclohexyloxy)-naphthalen-2-yl]-pentanoic acid was synthesized as per 4-nitro-4-[6-(trans-4-trifluoromethyl-cyclohexyloxy)-naphthalen-2-yl]-pentanoic acid (Example 280) in 93% yield, using 4-nitro-4-[5-trifluoromethyl-6-(cis-4-trifluoromethyl-cyclohexyloxy)-naphthalen-2-yl]-pentanoic acid methyl ester as the starting material.

Sources & evidence

ORD record: ord-bfcba23f51604be7b9ce6c334cf2b4b2
Source dataset: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08269043B2

Reaction notes

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