Trifluoroacetic acid → HCID 178464331, compound

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Reaction Steps

4-Amino-4-[5-trifluoromethyl-6-(trans-4-trifluoromethyl-cyclohexyloxy)-naphthalen-2-yl]-pentanoic acid was synthesized as per 4-amino-4-[6-(trans-4-trifluoromethyl-cyclohexyloxy)-naphthalen-2-yl]-pentanoic acid (Example 282) in 56% yield (as TFA salt), using 4-nitro-4-[5-trifluoromethyl-6-(trans-4-trifluoromethyl-cyclohexyloxy)-naphthalen-2-yl]-pentanoic acid as starting material. MS: m/z=500.20 [M+Na]+. 1H NMR (400 MHz, DMSO-d6) δ ppm: 12.23 (br. s., 1H), 8.53 (br. s., 3H), 8.22 (d, J=9.3 Hz, 1H), 8.12 (d, J=8.0 Hz, 1H), 8.05 (d, J=1.5 Hz, 1H), 7.72-7.80 (m, 2H), 4.62-4.73 (m, 1H), 2.35-2.42 (m, 1H), 2.21-2.34 (m, 2H), 2.07-2.20 (m, 3H), 1.88-2.05 (m, 3H), 1.66-1.78 (m, 3H), 1.40-1.60 (m, 4H).

Provenance & Evidence