Water → HCID 59408352, compound

Participants

Reaction Steps

20.0 g (52.5 mmol) of trimethyl-[4-(4′-propylbicyclohexyl-4-yl)phenylethynyl]silane are stirred for 48 h together with 8.71 g (63.0 mmol) of K2CO3 and 1.5 ml of water in 250 ml of methanol. The mixture is diluted with MTBE and neutralised using dil. hydrochloric acid. The aqueous phase is extracted with MTBE, and the combined organic phases are washed with water and sat. sodium chloride solution. The solution is dried using sodium sulfate and concentrated to completion. The crude product is recrystallised from n-heptane. 4′-(4-Ethynylphenyl)-4-propylbicyclohexyl is obtained as a colourless solid having an m.p. of 71° C.

Provenance & Evidence