Ethylene Glycol → HCID 59408350, compound

Participants

Reaction Steps

250 g (about 0.7 mol) of crude 4-(1,4-dioxaspiro[4.5]dec-8-yl)-1-(4-propylphenyl)cyclohexanol are heated on a water separator together with 13.2 g (69 mmol) of p-toluenesulfonic acid monohydrate and 40.7 ml (0.73 mol) of ethylene glycol in 800 ml of toluene. The solution is washed a number of times with water and dried using sodium sulfate. The crude product remaining after removal of the solvent is purified by chromatography (SiO2, n-heptane:MTBE=5:1). 8-[4-(4-Propylphenyl)cyclohex-3-enyl]-1,4-dioxaspiro[4.5]decane is obtained as a colourless solid.

Provenance & Evidence