HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 238922Generated: October 29, 2026
Pyridine → Ethyl 2-[3-fluoro-4-(metylsulfonylamino)phenyl]propionate
https://huagongshe.com/reaction/238922
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 2-(4-Amino-3-fluorophenyl)propionate | HCID 86609171 | — |
| Product | Ethyl 2-[3-fluoro-4-(metylsulfonylamino)phenyl]propionate | HCID 24754385 | 91% |
Reaction Steps
A solution of 2-(4-amino-3-fluorophenyl)propionate (1-13, 4 mM) and pyridine (10 ml) was dissoluted with methansulfonylchloride (6 mM) and was stirred at 0° C. for 10 minutes. The combined organic layers were washed with H2O and residue was purified by flash column chromatography on silica gel with EtOAc/hexanes (1:2) as eluant to afford ethyl 2-[3-fluoro-4-(metylsulfonylamino)phenyl]propionate compound (1-26, SU-658).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08642657B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-116ba5f3ec5347fcaaf9cd8bda8012b5 |
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| Source note | uspto-grants-2014_02 |
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