Potassium Carbonate → HCID 68659651, compound

Participants

Reaction Conditions

Reaction Steps

89.5 g (0.500 mol) of 2,5-dichlorobenzenethiol, 53.4 g (0.55 mol) of 3-fluoropyridine, 82.9 g (0.60 mol) of potassium carbonate, and 550 mL of anhydrous N,N′-dimethyl acetamide were weighed in a 2 L three-necked flask equipped with a stirrer, thermometer, cooling pipe, and nitrogen inlet tube. The reaction solution was heated to 100° C. for 3 hours under a nitrogen atmosphere using an oil bath. After confirming the disappearance of raw materials by way of thin-layer chromatography, the reaction liquid was allowed to cool to room temperature. Thereafter, the reaction liquid was gradually added to 3 L of water, and the product was solidified and filtered. The product obtained by filtering was dissolved in 2.5 L of toluene, and then washed with a sodium chloride solution using a separating funnel till the aqueous layer became neutral. The organic layer was dried using magnesium sulfate, and then the solvent was removed by an evaporator to obtain 2,5-dichlorophenyl pyridyl sulfide of an intermediate in an approximate yield amount of 129 g.

Provenance & Evidence