Potassium Carbonate → tert-Butyl 1-(4-bromophthalazin-1-yl)piperidin-4-yl(methyl)carbamate

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	N-methyl-2-pyrrolidone	HCID 13387	—
Reactant	4-N-Boc-4-N-Methyl-aminopiperidine	HCID 2756806	—
Reactant	1,4-Dibromophthalazine	HCID 59627392	—
Solvent	Water	HCID 962	—
Product	tert-Butyl 1-(4-bromophthalazin-1-yl)piperidin-4-yl(methyl)carbamate	HCID 59627406	95.7%

Reaction Conditions

Temperature	80 °C

Reaction Steps

Combine 1,4-dibromophthalazine (0.70 g, 2.38 mmol), N-methylpyrrolidone (7.0 mL), potassium carbonate (395 mg, 2.86 mmol), and methyl-piperidin-4-yl-carbamic acid tert-butyl ester (532 mg, 2.38 mmol). Heat at 80° C. overnight. Cool and pour into water. Collect the solid and dry in a vacuum oven at ambient temperature overnight to obtain the final product (0.96 g, 95%). ES/MS m/z (81Br) 421.0 (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08273742B2
Source dataset	uspto-grants-2012_09
ORD ID	ord-9c288a9dc95d4b52aea4f722d5f34449
Source note	uspto-grants-2012_09