Phenacyl bromide → Quinoxaline

Participants

Reaction Steps

To a magnetically stirred solution of the appropriate α-bromoacetophenone (1 eq) in 5 ml of ethanol was added the appropriate 1,2-phenylenediamine (2.7 eq), followed by DIPEA (3.4 eq). The resultant solution was stirred at room temperature overnight with an air atmosphere. The reaction was concentrated, then purified by reverse phase chromatography on a C-18 column using a 0 to 90% gradient of CH3CN in water, with both containing 0.05% TFA. Product containing fractions were lyophilized to give a powder.

Provenance & Evidence