Phenacyl bromide → Quinoxaline

Participants

Reaction Steps

To a magnetically stirred solution of the appropriate alpha-bromoacetophenone (1 eq) in 200 ml of ethanol was added the appropriate 1,2-phenylenediamine (2.4 eq), followed by addition of solid sodium acetate (3 eq). The resultant solution was warmed to reflux and stirred overnight with an air atmosphere. The product formed precipitates, and so the reaction was vacuum filtered, and the solids washed with 50 ml cold ethanol followed by washing with 50 ml 0.1 N HCl. The product was carried on without further purification.

Provenance & Evidence