2,2-Diphenylethylamine → HCID 11189896, compound

HRID 238927Notes

Reaction equation

HRID 238927 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:13]([CH3:17])[C:14]([OH:16])=O)[CH:5]=[CH:6][C:7]=1[NH:8][S:9]([CH3:12])(=[O:11])=[O:10].[C:18]1([CH:24]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:25][NH2:26])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.C(NC(=O)C(C1C=CC(NS(C)(=O)=O)=C(F)C=1)C)(C1C=CC=CC=1)C1C=CC=CC=1>>[C:27]1([CH:24]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:25][NH:26][C:14](=[O:16])[CH:13]([C:4]2[CH:5]=[CH:6][C:7]([NH:8][S:9]([CH3:12])(=[O:10])=[O:11])=[C:2]([F:1])[CH:3]=2)[CH3:17])[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

Participants

4

Reactant 3

HCID 775752,2-DiphenylethylamineHCID 11327778HCID 11327778, compoundHCID 24754387HCID 24754387, compound

Product 1

HCID 11189896HCID 11189896, compound

Procedure

Through similar procedure to that in Example 1-5 excepting using 2-[3-Fluoro-4-(methylsulfonylamino)phenyl]propionic acid (1-38) with the corresponding 2,2-Diphenylethylamine compound as a starting material, N-Benzhydryl-2-[3-fluoro-4-(methylsulfonylamino)phenyl]propionamide having following physicochemical properties was synthesized:

Workup

  1. customwas synthesized

Sources & evidence

ORD record
ord-2c598dd8fa664f64a3fbe315842f3da2
Source dataset
uspto-grants-2014_02
Patent number
US08642657B2

Reaction notes

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