HCID 11339467, compound → HCID 57403411, compound

HRID 238928Notes

Reaction equation

HRID 238928 reaction equation
COC1[CH:4]=[C:5]([C:14](C)(C)C(O)=O)[CH:6]=CC=1NS(C)(=O)=O.[CH3:20][C:21]1[CH:22]=[C:23]([CH2:28][CH2:29][CH2:30][NH:31][C:32](=[O:49])[C:33]([C:36]2[CH:41]=[CH:40][C:39]([NH:42][S:43]([CH3:46])(=[O:45])=[O:44])=[C:38](OC)[CH:37]=2)([CH3:35])[CH3:34])C=CC=1C>>[C:5]([C:22]1[CH:21]=[CH:20][C:29]([CH2:30][NH:31][C:32](=[O:49])[C:33]([C:36]2[CH:41]=[CH:40][C:39]([NH:42][S:43]([CH3:46])(=[O:44])=[O:45])=[CH:38][CH:37]=2)([CH3:35])[CH3:34])=[CH:28][CH:23]=1)([CH3:14])([CH3:6])[CH3:4]

Participants

3

Reactant 2

HCID 11339467HCID 11339467, compoundHCID 11392052HCID 11392052, compound

Product 1

HCID 57403411HCID 57403411, compound

Procedure

Through similar procedure to that in Example 1-5 excepting using 2-(3-methoxy-4-(methylsulfonylamino)phenyl)-2-methylpropionic acid (8-12), N-[3-(3,4-Dimethylphenyl)propyl]-2-[3-methoxy-4-(methylsulfonylamino)phenyl]-2-methylpropionamide (9-6, CHK-600) having following physicochemical properties was synthesized:

Workup

  1. customwas synthesized

Sources & evidence

ORD record
ord-ad2f8878c0794ee6a9f553c4e93b76e9
Source dataset
uspto-grants-2014_02
Patent number
US08642657B2

Reaction notes

Loading…