2-Chloro-4-cyanopyridine → HCID 67455275, compound

HRID 2389284Notes

Reaction equation

HRID 2389284 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][N:3]=1.[C:10]([C:14]1[N:15]([CH2:32][CH:33]2[CH2:38][CH2:37][O:36][CH2:35][CH2:34]2)[CH:16]=[C:17]([Sn](CCCC)(CCCC)CCCC)[N:18]=1)([CH3:13])([CH3:12])[CH3:11]>>[C:10]([C:14]1[N:15]([CH2:32][CH:33]2[CH2:38][CH2:37][O:36][CH2:35][CH2:34]2)[CH:16]=[C:17]([C:2]2[CH:7]=[C:6]([CH:5]=[CH:4][N:3]=2)[C:8]#[N:9])[N:18]=1)([CH3:13])([CH3:11])[CH3:12]

Participants

3

Reactant 2

HCID 5686382-Chloro-4-cyanopyridineHCID 67456341HCID 67456341, compound

Product 1

HCID 67455275HCID 67455275, compound

Procedure

The title compound 124 (70 mg, 0.22 mmol, yield: 68%) was obtained in the same manner as in step 3 of Example 101, using 2-chloro-4-cyanopyridine and 2-tert-butyl-1-(tetrahydropyran-4-yl)methyl-4-tributylstannyl-1H-imidazole obtained in step 1 of Example 108.

Sources & evidence

ORD record
ord-fec7b6c49ab54ef5b4c8cca3e5e3aa3c
Source dataset
uspto-grants-2012_09
Patent number
US08273738B2

Reaction notes

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