Chloroacetaldehyde → HCID 67458178, compound

Participants

Reaction Steps

6-Amino-5-bromo-N-ethyl-N-methylnicotinamide (250 mg, 0.97 mmol) obtained in Step 1 of Example 170 was dissolved in ethanol (2.5 mL), and a 50% aqueous chloroacetaldehyde solution was added thereto, and the mixture was stirred overnight under reflux. After the mixture was left to cool to room temperature, an aqueous sodium hydrogen carbonate solution was added thereto, and the mixture was extracted with a chloroform/isopropanol (6/1) mixed solution. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform/methanol=98/2) to give 8-bromo-N-ethyl-N-methylimidazo[1,2-a]pyridine-6-carboxamide (65 mg, 0.23 mmol, yield: 24%).

Provenance & Evidence