Ethanol → HCID 67457278, compound

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Reaction Steps

Compound 1 (0.17 g, 0.53 mmol) obtained in Example 1 was dissolved in ethanol (60 mL), and a 2 mol/L aqueous sodium hydroxide solution (60 mL, 120 mmol) was added thereto, and then, the mixture was refluxed overnight. After the mixture was left to cool to room temperature, the solvent was evaporated under reduced pressure. To the residue, 2 mol/L hydrochloric acid was added to adjust the pH of the mixture to 4. Then, the mixture was extracted with chloroform, and the organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate. Then, the solvent was evaporated under reduced pressure to give the title compound a (178 mg, 0.52 mmol, yield: 98%).

Provenance & Evidence