Sodium Bicarbonate → HCID 67454392, compound

Participants

Reaction Conditions

Reaction Steps

Compound 136 (427 mg, 1.28 mmol) obtained in Example 136 was dissolved in DMF-n-propanol (1/3) (12 mL), and palladium acetate (28.6 mg, 0.128), 2,2′-bis(diphenylphosphino)-1,1′-binaphtyl (79.4 mg, 0.128 mmol), and potassium acetate (151 mg, 1.54 mmol) were added thereto, and the mixture was stirred at 80° C. for 3.5 hours under a carbon monoxide atmosphere. To the mixture, an aqueous sodium hydrogen carbonate solution was added, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography to give 2-[2-tert-butyl-1-(tetrahydropyran-4-ylmethyl)-1H-imidazol-4-yl]pyrazine-2-carboxylic acid n-propyl ester (419 mg, 1.08 mmol, yield: 85%).

Provenance & Evidence