HCID 57935253, compound → HCID 58022574, compound

HRID 2389301Notes

Reaction equation

HRID 2389301 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]([CH3:16])[N:6]=[C:7]([O:13][CH2:14][CH3:15])[C@H:8]([CH:10]([CH3:12])[CH3:11])[N:9]=1)[CH3:2].[Cl:17][C:18]1[CH:23]=[C:22]([O:24][C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:34])([F:33])[F:32])[CH:26]=2)[CH:21]=[CH:20][C:19]=1[CH2:35][CH2:36]I>>[Cl:17][C:18]1[CH:23]=[C:22]([O:24][C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:34])([F:33])[F:32])[CH:26]=2)[CH:21]=[CH:20][C:19]=1[CH2:35][CH2:36][C@:5]1([CH3:16])[C:4]([O:3][CH2:1][CH3:2])=[N:9][C@@H:8]([CH:10]([CH3:11])[CH3:12])[C:7]([O:13][CH2:14][CH3:15])=[N:6]1

Participants

3

Reactant 2

HCID 57935253HCID 57935253, compoundHCID 68586903HCID 68586903, compound

Product 1

HCID 58022574HCID 58022574, compound

Procedure

(5S)-3,6-diethoxy-5-isopropyl-2-methyl-2,5-dihydropyrazine and 2-chloro-1-(2-iodoethyl)-4-(3-trifluoromethylphenoxy)benzene were reacted in the same manner as in Example 1 to obtain the target product as a colorless oil.

Sources & evidence

ORD record
ord-4b8202e8eb174ff081e6285efb5e0ae8
Source dataset
uspto-grants-2012_09
Patent number
US08273748B2

Reaction notes

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