Sodium Bicarbonate → HCID 24880181, compound

Participants

Reaction Steps

To a solution of the compound of Example 27 (9.3 g) in ethyl acetate (450 mL) was added saturated aqueous sodium hydrogen carbonate solution (450 mL), and the resultant solution was stirred at room temperature for 10 minutes. The organic layer was washed with water and saturated brine in that order, and then dried over anhydrous sodium sulfate. The solvent was evaporated, and the resultant residue was purified by NH-silica gel column chromatography (ethyl acetate:methanol=4:1) to obtain the target product (8.9 g) as a white powder.

Provenance & Evidence