Water → HCID 68535297, compound

Participants

Reaction Steps

A mixture of 4-oxo-5,5-diphenylpentanoic acid (2.47 g) and hydrazine monohydrate (1.4 mL) in toluene (49 mL) was refluxed for 3.5 hours. Water and EtOAc were poured into the reaction mixture. The organic layer was separated, washed with saturated NaHCO3 aqueous solution and brine, and dried over anhydrous MgSO4, filtered and evaporated in vacuo. The residue was washed with MeCN to give 6-(diphenylmethyl)-4,5-dihydropyridazin-3(2H)-one (0.85 g) as white powder.

Provenance & Evidence