反应详情

温度

70 °C

To a suspension of ethyl N-[2-acetamido-3-(benzyloxy)phenyl]glycinate (2.82 g) in EtOH (28.2 mL) was added H2SO4 (1.62 g) at ambient temperature. The mixture was stirred at 70° C. for 1 hour. After cooling, the reaction mixture was added ice and alkalized with 2M NaOH aqueous solution (pH=8) under ice cooling. The formed precipitate was collected by filtration and washed with water to give ethyl [4-(benzyloxy)-2-methyl-1H-benzimidazol-1-yl]acetate (2.65 g) as a white solid.

1. temperatureAfter cooling
2. additionthe reaction mixture was added ice
3. filtrationThe formed precipitate was collected by filtration
4. washwashed with water