Sodium Iodide → HCID 68535459, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-[3-(diphenylmethyl)-6-oxopyridazin-1(6H)-yl]ethyl methanesulfonate (200 mg), ethyl 4-(3-hydroxyphenoxy)butanoate (140 mg), K2CO3 (93 mg), sodium iodide (94 mg), and DMF (2 mL) was stirred at 80° C. for 2 hours. After cooling, the reaction mixture was diluted with EtOAc (50 mL) and washed with water (30 mL) and brine (30 mL) two times. The organic layer was dried over anhydrous MgSO4, filtered and evaporated in vacuo to give crude oil. The crude oil was purified by silica gel column chromatography (n-hexane:EtOAc=1:1) to give ethyl 4-(3-{2-[3-(diphenylmethyl)-6-oxopyridazin-1(6H)-yl]ethoxy}phenoxy)butanoate (87 mg) as a pale yellow oil.

Provenance & Evidence