Hydrochloric Acid → HCID 14896943, compound

Participants

Reaction Steps

1.59M n-Butyllithium solution in n-hexane (25 mL) was added dropwise to a stirred solution of 1,1′-methylenedibenzene (6.73 g) in THF (75 mL) below 35° C. under N2 gas atmosphere. The reaction mixture was added dropwise to a solution of dihydrofuran-2,5-dione(2 g) in THF (50 mL) below 25° C. After stirring for 4 hours. 1M HCl aqueous solution (45 mL) and EtOAc were poured into the reaction mixture. The organic layer was separated and was washed with water and brine, and dried over anhydrous MgSO4, filtered and evaporated in vacuo. The residue was purified by silica gel column chromatography (DCM:MeOH). The desired fractions were collected and evaporated in vacuo to give 4-oxo-5,5-diphenylpentanoic acid (2.48 g) as a yellow solid.

Provenance & Evidence