3-(3'-Hydroxyphenyl)propionic acid → Ethyl 3-(3-hydroxyphenyl)propanoate

Participants

Reaction Steps

To a solution of 3-(3-hydroxyphenyl)propanoic acid (135 g) in EtOH (670 mL) was added concentrated H2SO4 (34.7 mL) at ambient temperature and the mixture was refluxed for 24 hours. After cooled to ambient temperature, the mixture was evaporated in vacuo. Water (400 mL) was added to the mixture and the mixture was extracted with EtOAc (600 mL). The organic layer was washed with brine, dried over anhydrous MgSO4, filtered and evaporated in vacuo to afford ethyl 3-(3-hydroxyphenyl)propanoate (163 g) as a slightly yellow oil.

Provenance & Evidence