Aluminium lithium hydride → HCID 68535380, compound

Participants

Reaction Steps

To a stirring solution of tert-butyl 3-(3-methoxy-3-oxopropyl)-1H-indole-1-carboxylate (50 mg) was added lithium aluminum hydride (6 mg) at 0° C. After 1 hour, to the mixture was added water, and the resulting mixture was extracted with EtOAc. The organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered and evaporated in vacuo. The residue was purified by silica gel column chromatography (n-hexane:EtOAc=5:1) to give tert-butyl 3-(3-hydroxypropyl)-1H-indole-1-carboxylate (45 mg).

Provenance & Evidence