Tetrahydrofuran → HCID 56998111, compound

Participants

Reaction Steps

To a solution of (2E)-3-{3-[(1E)-3-ethoxy-3-oxo-1-propen-1-yl]phenyl}acrylic acid (10.40 g) in a mixed solvent(THF:EtOAc=150 mL:100 mL) was added 10% Palladium on activated carbon (50% wet, 1.6 g) at ambient temperature. The reaction mixture was stirred under hydrogen atmosphere at ambient temperature for 5 hours and was filtered through celite. The filtrate was evaporated in vacuo to afford 3-[3-(3-ethoxy-3-oxopropyl)phenyl]propanoic acid (10.57 g) as a colorless oil.

Provenance & Evidence