Carbon tetrabromide → HCID 68535392, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-[4-(hydroxymethyl)-1,3-oxazol-2-yl]-1H-indole-1-carboxylate (330 mg) and PPh3 (330 mg) in DCM (6.6 mL) was added portionwise carbon tetrabromide (418 mg) at ambient temperature and the mixture was stirred at the same temperature for 4 hours. The resulting mixture was evaporated in vacuo and the residue was purified by silica gel column chromatography(n-hexane:EtOAc=5:1) to afford tert-butyl 4-[4-(bromomethyl)-1,3-oxazol-2-yl]-1H-indole-1-carboxylate (396 mg) as a white solid.

Provenance & Evidence