Water → HCID 68535543, compound

Participants

Reaction Steps

To a stirring solution of 5-(diphenylmethyl)-1-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-2(1H)-pyridinone (46 mg) in MeOH (1.38 mL) was added pyridium p-toluenesulfonate (9 mg) at ambient temperature. After 48 hours, water was added and the mixture was extracted with EtOAc. The organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered and evaporated in vacuo. The residue was purified by preparative thin-layer chromatography (chloroform:EtOAc=1:2) to give 5-(diphenylmethyl)-1-(2-hydroxyethyl)-2(1H)-pyridinone (20 mg).

Provenance & Evidence