Hydrochloric Acid → HCID 86637914, compound

Participants

Reaction Steps

To a solution of ethyl {3-[3-(tetrahydro-2H-pyran-2-yloxy)propoxy]phenoxy}acetate (3.54 g. crude) in EtOH (34.5 mL) was added 1M HCl aqueous solution (20.4 mL) at ambient temperature. The mixture was stirred for an hour at ambient temperature. The reaction mixture was neutralized with saturated NaHCO3 aqueous solution and evaporated in vacuo. The resulting residue was dissolved in EtOAc (50 mL) and washed with brine (30 mL). The organic layer was dried over anhydrous MgSO4, filtered and evaporated in vacuo to give crude oil. The crude oil was purified by silica gel column chromatography (n-hexane:EtOAc=2:1-1:1) to give ethyl [3-(3-hydroxypropoxy)phenoxy]acetate (2.1 g) as a colorless oil.

Provenance & Evidence