Aluminum(III) Chloride → HCID 68535256, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-(2-bromophenyl)-2-methoxypyridine (7.2 g) in 1,2-dichloroethane (75 mL) was added aluminum chloride (9.09 g) at ambient temperature. The reaction mixture was stirred at 50° C. for 3 hours. The reaction mixture was poured into ice and was extracted with a mixed solvent (THF:EtOAc=3:1) and the organic layer was washed with brine, dried over anhydrous MgSO4, filtered and evaporated in vacuo. The residue was added silica gel (150 g), and the mixture of the filtrate and silica gel was evaporated in vacuo. The residue was purified by silica gel column chromatography (chloroform:MeOH=97:3) to afford 5-(2-bromophenyl)pyridin-2(1H)-one (4.72 g) as yellow crystals.

Provenance & Evidence