Trimethylsilyl iodide → HCID 178424150, compound

Participants

Reaction Steps

To a solution of 2-methoxy-5-(2′-methylbiphenyl-2-yl)pyridine (2.20 g) in DCM (50 mL) was added iodo(trimethyl) silane (5.0 g) at ambient temperature. The reaction mixture was stirred at ambient temperature for 4 days. To the reaction mixture was added brine (50 mL). The mixture was extracted with EtOAc and the organic layer was dried over anhydrous MgSO4, filtered and evaporated in vacuo. The residue was purified by silica gel column chromatography (EtOAc:chloroform=3:7) to afford 5-(2′-methylbiphenyl-2-yl)pyridin-2-ol (1.35 g) as pale yellow crystals.

Provenance & Evidence