Ethyl oxoacetate → HCID 68535649, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1,1-bis(4-fluorophenyl)acetone (2.4 g) and ethyl glyoxylate (47% solution in toluene, 2.1 g) was stirred at 130° C. for 3 days. The reaction mixture was cooled to ambient temperature. The mixture was purified by silica gel column chromatography (n-hexane:EtOAc=4:1) to give ethyl 5,5-bis(4-fluorophenyl)-2-hydroxy-4-oxopentanoate (800 mg) as a brown oil.

Provenance & Evidence