Ethyl bromoacetate → HCID 86637916, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-(diphenylmethyl)-1-[(2E)-3-(1H-indol-4-yl)-2-propen-1-yl]-2(1H)-pyridinone (80 mg), K2CO3 (80 mg) and benzyltriethylammonium chloride (8.8 mg) in 2-butanone (1 mL) was added ethyl bromoacetate (96 mg) at ambient temperature. The reaction mixture was stirred for 5 hours at 80° C. The resulting mixture was diluted with EtOAc and washed successively with water and brine. The organic layer was dried over anhydrous MgSO4, filtered and evaporated in vacuo. The residue was purified by silica gel column chromatography (chloroform:MeOH=100:0-97:3) to give ethyl (4-{(1E)-3-[5-(diphenylmethyl)-2-oxo-1(2H)-pyridinyl]-1-propen-1-yl}-1H -indol-1-yl)acetate.

Provenance & Evidence