Methyl iodide → HCID 59145199, compound

Participants

Reaction Steps

To a solution of (3-{3-[5-(diphenylmethyl)-2-oxo-1(2H)-pyridinyl]propyl}phenoxy)acetic acid (100 mg) in DMF (2 mL) was added K2CO3 (46 mg) and iodomethane (41 mg) at ambient temperature. The reaction mixture was stirred for 5 hours at the same temperature. The resulting mixture was diluted with EtOAc and washed successively with water and brine. The organic layer was dried over anhydrous MgSO4, filtered and evaporated in vacuo. The residue was purified by silica gel column chromatography (n-hexane:EtOAc=80:20-40:60) to give methyl (3-{3-[5-(diphenylmethyl)-2-oxo-1(2H)-pyridinyl]propyl}phenoxy)acetate-.

Provenance & Evidence