Sodium Hydroxide → HCID 86637918, compound

HRID 2389388Notes

Reaction equation

HRID 2389388 reaction equation
[C:1]([N:9]([CH2:24][CH2:25][CH:26]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:10][CH2:11][CH2:12][C:13]1[CH:14]=[C:15]([CH:21]=[CH:22][CH:23]=1)[O:16][CH2:17][C:18]([OH:20])=[O:19])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+:40]>CO>[C:1]([N:9]([CH2:24][CH2:25][CH:26]([C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[CH2:10][CH2:11][CH2:12][C:13]1[CH:14]=[C:15]([CH:21]=[CH:22][CH:23]=1)[O:16][CH2:17][C:18]([O-:20])=[O:19])(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1.[Na+:40]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57400864HCID 57400864, compound

Product 1

HCID 86637918HCID 86637918, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of (3-{3-[benzoyl(3,3-diphenylpropyl)amino]propyl}phenoxy)acetic acid (110 mg) in MeOH (1 mL) was added 1M NaOH aqueous solution (0.217 mL) at ambient temperature. The mixture was stirred for 0.5 hours at the same temperature. The resulting mixture was evaporated in vacuo. The residue was triturated with diisopropylether to give a sodium (3-{3-[benzoyl(3,3-diphenylpropyl)amino]propyl}phenoxy)acetate.

Workup

  1. customThe resulting mixture was evaporated in vacuo
  2. customThe residue was triturated with diisopropylether

Sources & evidence

ORD record
ord-f475f0730ffc49a5b358b2138f5527a9
Source dataset
uspto-grants-2012_09
Patent number
US08273745B2

Reaction notes

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