HCID 11153913, compound → HCID 11418768, compound

HRID 238942Notes

Reaction equation

HRID 238942 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:13]([NH2:15])[CH3:14])[CH:5]=[CH:6][C:7]=1[NH:8][S:9]([CH3:12])(=[O:11])=[O:10].[C:16]([C:20]1[CH:43]=[CH:42][C:23]([CH2:24][NH:25][C:26](NC(C2C=CC(NS(C)(=O)=O)=CC=2)C)=[O:27])=[CH:22][CH:21]=1)([CH3:19])([CH3:18])[CH3:17]>>[C:16]([C:20]1[CH:43]=[CH:42][C:23]([CH2:24][NH:25][C:26]([NH:15][CH:13]([C:4]2[CH:5]=[CH:6][C:7]([NH:8][S:9]([CH3:12])(=[O:11])=[O:10])=[C:2]([F:1])[CH:3]=2)[CH3:14])=[O:27])=[CH:22][CH:21]=1)([CH3:19])([CH3:17])[CH3:18]

Participants

3

Reactant 2

HCID 11153913HCID 11153913, compoundHCID 21097518N-[4-(1-Aminoethyl)-2-fluorophenyl]methanesulfonamide

Product 1

HCID 11418768HCID 11418768, compound

Procedure

Through similar procedure to that in Example 102 excepting 1-[3-Fluoro-4-(methylsulfonylamino)phenyl]ethyl amine (13-12) as a starting material, N-(4-t-Butylbenzyl)-N′-{1-[4-(methylsulfonylamino)phenyl]ethyl}urea (23-1, MK-82) having following physicochemical properties was synthesized:

Workup

  1. customwas synthesized

Sources & evidence

ORD record
ord-8511fd5fb5944a0ab3fd47d3ea57f1db
Source dataset
uspto-grants-2014_02
Patent number
US08642657B2

Reaction notes

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