Acetone → HCID 178454825, compound

Participants

Reaction Steps

A suspension of tert-butyl (2-mercapto-benzoimidazol-1-yl)-acetate (Precursor 3-I, 1 g, 3.79 mmol), 1-(3-chloromethyl-piperidin-1-yl)-butan-1-one (alkylating agent I-01d, 771 mg, 3.79 mmol) and K2CO3 (1.05 g, 7.58 mmol) in acetone (10 ml) is refluxed for 36 h. The crude mixture is filtered over a fritted-funnel and the solvent evaporated in vacuo. The resulting brown gum is purificated by column chromatography on silica-gel (AcOEt/heptane, 3:7 to 1:1), yielding the title compound (802 mg) in 49% as a colourless oil: tR=2.19 min (LC-1), ESI-MS (pos.): m/z 432.24 [M+H]+.

Provenance & Evidence