HCID 131729956, compound → HCID 70696660, compound

Participants

Reaction Steps

A solution of tert-butyl[2-(5-acetyl-2-methoxy-benzylsulfanyl)-5-formyl-benzoimidazol-1-yl]-acetate (Precursor 5-HCO—H-11b, 16 mg, 0.035 mmol) in TFA/dichloromethane (1:1, 4 ml) is allowed to stir overnight at rt. The solvents are removed under a stream of air and the resulting products are dried under high vacuum. This yields the title compound (14 mg) in 100% as a yellow solid: tR=0.94 min (LC-3), ESI-MS (pos.): m/z 398.86 [M+H]+, ESI-MS (neg.): m/z 397.06 [M−H]+; 1H-NMR (DMSO-d6): δ (ppm) 2.46 (s, 3H, COCH3), 3.88 (s, 3H, OCH3), 4.59 (s, 2H, SCH2), 4.96 (s, 2H, CH2CO2), 7.11 (d, 1Harom), 7.65 (d, 1Harom), 7.74 (d, 1Harom), 7.90 (dd, 1Harom), 8.06 (d, 1Harom), 8.12 (d, 1Harom), 10.01 (s, 1H, CHO).

Provenance & Evidence