Ethyl Acetate → HCID 67359723, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-chloro-2-fluoronitrobenzene (3.0 g, 17.0 mmol) in DMF (8.7 mL), 4-fluorophenol (2.0 g, 17.9 mmol) and potassium carbonate (2.46 g, 17.9 mmol) were successively added, and the mixture was stirred at 70° C. for 2 hours. After the reaction, the mixture was cooled to room temperature and ethyl acetate was added to the mixture. After the organic phase was washed with water (30 mL), 1N sodium hydroxide (aq., 30 mL) and saturated brine (20 mL), it was dried with sodium sulfate. The solvent was distilled off under reduced pressure to give 4-chloro-2-(4-fluorophenoxy)-1-nitrobenzene as a crude product. The obtained compound was used for the subsequent reaction without further purification.

Provenance & Evidence