HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 178512588, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-butyl N-[[(2-chloro-4-pyridinyl)amino]-[(2-methylpropan-2-yl)oxycarbonylamino]methylidene]carbamate | HCID 178454301 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178512588 | HCID 178512588 | 110.8% |
Reaction Steps
To a solution of 43.67 g (0.117 mol) of di-tert-butyl{(Z)-[(2-chloropyridin-4-yl)amino]methylylidene}biscarbamate in dichloromethane (800 ml) at room temperature were added 81.64 ml of trifluoroacetic acid (1.06 mol). The reaction mixture was stirred at room temperature for 2 days, concentrated in vacuo, triturated with 100 ml of pentane, and upon standing crystallized to yield 51.68 g of 1-(2-chloropyridin-4-yl)guanidine bis(trifluoroacetate) (yield=99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273759B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-b8beae96f0734e4e80f91198dfc57f8d |
| Source note | uspto-grants-2012_09 |