4'-Bromo-2,2,2-trifluoroacetophenone → tert-Butyl (4-{[4-methoxy-4'-(2,2,2-trifluoro-acetyl)-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamate

Participants

Role	Name	HCID	Charge
Reactant	4'-Bromo-2,2,2-trifluoroacetophenone	HCID 603866	—
Reactant	3-{[4-(BOC-methyl-amino)-cyclohexylamino]-methyl}-4-methoxy-benzene boronic acid	HCID 25208191	—
Product	tert-Butyl (4-{[4-methoxy-4'-(2,2,2-trifluoro-acetyl)-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamate	HCID 59683508	—

Boronic acid 4 (620 mg, 1.60 mmol) is coupled to 4′-bromo-2,2,2-trifluoroacetophenone (400 mg, 1.60 mmol) using Method B to give the title compound.