3-Chlorobenzo(b)thiophene-2-carbonyl chloride → tert-Butyl (4-{(3-chloro-benzo[b]thiophene-2-carbonyl)-[4-methoxy-4'-(2,2,2-trifluoro-acetyl)-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamate

Participants

Role	Name	HCID	Charge
Reactant	3-Chlorobenzo(b)thiophene-2-carbonyl chloride	HCID 519898	—
Reactant	tert-Butyl (4-{[4-methoxy-4'-(2,2,2-trifluoro-acetyl)-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamate	HCID 59683508	—
Product	tert-Butyl (4-{(3-chloro-benzo[b]thiophene-2-carbonyl)-[4-methoxy-4'-(2,2,2-trifluoro-acetyl)-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamate	HCID 59683634	—

Reaction Steps

Biaryl amine 16 (467 mg, 0.90 mmol) is treated with 3-chlorobenzo-[b]thiophene-2-carbonyl chloride (290 mg, 1.26 mmol) using Method D to give the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08273747B2
Source dataset	uspto-grants-2012_09
ORD ID	ord-46f563a0a6aa4a74bb6569006700599c
Source note	uspto-grants-2012_09