3-Bromobenzonitrile → tert-Butyl {4-[(3'-cyano-4-methoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate

関与物質

役割	名称	HCID	仕込み量
反応物	3-Bromobenzonitrile	HCID 23381	—
反応物	3-{[4-(BOC-methyl-amino)-cyclohexylamino]-methyl}-4-methoxy-benzene boronic acid	HCID 25208191	—
生成物	tert-Butyl {4-[(3'-cyano-4-methoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate	HCID 59683521	—

Boronic acid 4 (359 mg, 0.92 mmol) is coupled to 3-bromobenzonitrile (200 mg, 1.10 mmol) using Method B to give the title compound.