1-Bromo-4-(trifluoromethoxy)benzene → tert-Butyl {4-[(4-methoxy-4'-trifluoromethoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate

Participants

Role	Name	HCID	Charge
Reactant	1-Bromo-4-(trifluoromethoxy)benzene	HCID 521008	—
Reactant	3-{[4-(BOC-methyl-amino)-cyclohexylamino]-methyl}-4-methoxy-benzene boronic acid	HCID 25208191	—
Product	tert-Butyl {4-[(4-methoxy-4'-trifluoromethoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate	HCID 59683565	—

Boronic acid 4 (271 mg, 0.69 mmol) is coupled to 1-bromo-4-(trifluoromethoxy)benzene (200 mg, 0.83 mmol) using Method B to give the title compound.