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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2389580Generated: October 27, 2026

p-Bromochlorobenzene → tert-Butyl {4-[(4'-chloro-4-methoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate

https://huagongshe.com/reaction/2389580

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-BromochlorobenzeneHCID 7806—
Reactant3-{[4-(BOC-methyl-amino)-cyclohexylamino]-methyl}-4-methoxy-benzene boronic acidHCID 25208191—
Producttert-Butyl {4-[(4'-chloro-4-methoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamateHCID 59683614—

Reaction Steps

Boronic acid 4 (342 mg, 0.87 mmol) is coupled to 1-bromo-4-chlorobenzene (200 mg, 1.05 mmol) using Method B to give the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08273747B2
Source datasetuspto-grants-2012_09
ORD IDord-9ccf5f20fb6940e3a94e192539fce27c
Source noteuspto-grants-2012_09