HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Bromochlorobenzene → tert-Butyl {4-[(4'-chloro-4-methoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Bromochlorobenzene | HCID 7806 | — |
| Reactant | 3-{[4-(BOC-methyl-amino)-cyclohexylamino]-methyl}-4-methoxy-benzene boronic acid | HCID 25208191 | — |
| Product | tert-Butyl {4-[(4'-chloro-4-methoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate | HCID 59683614 | — |
Reaction Steps
Boronic acid 4 (342 mg, 0.87 mmol) is coupled to 1-bromo-4-chlorobenzene (200 mg, 1.05 mmol) using Method B to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273747B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-9ccf5f20fb6940e3a94e192539fce27c |
| Source note | uspto-grants-2012_09 |