3-Chlorobenzo(b)thiophene-2-carbonyl chloride → HCID 59683489, compound

HRID 2389586Notes

Reaction equation

HRID 2389586 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:5][C:4]=1[CH2:15][NH:16][CH:17]1[CH2:22][CH2:21][CH:20]([N:23]([CH3:31])[C:24](=[O:30])[O:25][C:26]([CH3:29])([CH3:28])[CH3:27])[CH2:19][CH2:18]1.[Cl:32][C:33]1[C:34]2[CH:44]=[CH:43][CH:42]=[CH:41][C:35]=2[S:36][C:37]=1[C:38](Cl)=[O:39]>>[Cl:32][C:33]1[C:34]2[CH:44]=[CH:43][CH:42]=[CH:41][C:35]=2[S:36][C:37]=1[C:38]([N:16]([CH2:15][C:4]1[CH:5]=[C:6]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:7]=[CH:8][C:3]=1[O:2][CH3:1])[CH:17]1[CH2:18][CH2:19][CH:20]([N:23]([CH3:31])[C:24](=[O:30])[O:25][C:26]([CH3:28])([CH3:27])[CH3:29])[CH2:21][CH2:22]1)=[O:39]

Participants

3

Reactant 2

HCID 5198983-Chlorobenzo(b)thiophene-2-carbonyl chlorideHCID 59683558HCID 59683558, compound

Product 1

HCID 59683489HCID 59683489, compound

Procedure

Biaryl amine 46 (423 mg, 1.00 mmol) is treated with 3-chloro-benzo[b]thiophene-2-carbonyl chloride (507 mg, 2.20 mmol) using Method D to give the title compound.

Sources & evidence

ORD record
ord-09a995660e0e42fb90b40587aec2a4ca
Source dataset
uspto-grants-2012_09
Patent number
US08273747B2

Reaction notes

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