HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chlorobenzo(b)thiophene-2-carbonyl chloride → tert-Butyl (4-{(3-chloro-benzo[b]thiophene-2-carbonyl)-[4'-(formyl-methyl-amino)-4-methoxy-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chlorobenzo(b)thiophene-2-carbonyl chloride | HCID 519898 | — |
| Reactant | tert-Butyl (4-{[4'-(formyl-methyl-amino)-4-methoxy-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamate | HCID 25208192 | — |
| Product | tert-Butyl (4-{(3-chloro-benzo[b]thiophene-2-carbonyl)-[4'-(formyl-methyl-amino)-4-methoxy-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamate | HCID 25208343 | — |
Reaction Steps
Biaryl amine 52 (325 mg, 0.64 mmol) is treated with 3-chloro-benzo[b]thiophene-2-carbonyl chloride (171 mg, 0.74 mmol) using Method D to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273747B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-e4bf2533db21485297a3273a4a2ee3ae |
| Source note | uspto-grants-2012_09 |