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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2389591Generated: October 26, 2026

4-Bromobenzamide → tert-Butyl {4-[(4'-carbamoyl-4-methoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate

https://huagongshe.com/reaction/2389591

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-BromobenzamideHCID 69683—
Reactant3-{[4-(BOC-methyl-amino)-cyclohexylamino]-methyl}-4-methoxy-benzene boronic acidHCID 25208191—
Producttert-Butyl {4-[(4'-carbamoyl-4-methoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamateHCID 59683480—

Reaction Steps

Boronic acid 4 (326 mg, 0.83 mmol) is coupled to 4-bromobenzamide (200 mg, 0.99 mmol) using Method B to give the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08273747B2
Source datasetuspto-grants-2012_09
ORD IDord-8aefda57777140c18d13875bbc12e657
Source noteuspto-grants-2012_09