HRID2389605

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID231310

5-Bromopyrimidin-2(1H)-imine

C4H4BrN3

结构：CCOc1ccc(B(O)O)cc1CN(C(=O)c1sc2ccccc2c1Cl)C1CCC(N(C)C(=O)OC(C)(C)C)CC1

HCID59683494

未命名化合物

PRODUCTS

生成物

结构：CCOc1ccc(-c2cnc(N)nc2)cc1CN(C(=O)c1sc2ccccc2c1Cl)C1CCC(NC)CC1.Cl.Cl

HCID68314432

未命名化合物

PROCEDURE

实验过程

The title compound is prepared from boronic acid 12 (25 mg, 42 μmol) and 2-amino-5-bromopyrimidine (6.0 mg, 35 μmol) in accordance with Method L2.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d1a9708befe44483998b37b7479951df
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08273747B2
来源说明: uspto-grants-2012_09

反应 SMILES

[C:1]([N:8](C)[CH:9]1[CH2:14][CH2:13][CH:12]([N:15]([CH2:28][C:29]2[CH:30]=[C:31](B(O)O)[CH:32]=[CH:33][C:34]=2[O:35][CH2:36][CH3:37])[C:16]([C:18]2[S:22][C:21]3[CH:23]=[CH:24][CH:25]=[CH:26][C:20]=3[C:19]=2[Cl:27])=[O:17])[CH2:11][CH2:10]1)(OC(C)(C)C)=O.[NH2:42][C:43]1[N:48]=[CH:47][C:46](Br)=[CH:45][N:44]=1>>[ClH:27].[ClH:27].[NH2:42][C:43]1[N:48]=[CH:47][C:46]([C:31]2[CH:32]=[CH:33][C:34]([O:35][CH2:36][CH3:37])=[C:29]([CH:30]=2)[CH2:28][N:15]([CH:12]2[CH2:11][CH2:10][CH:9]([NH:8][CH3:1])[CH2:14][CH2:13]2)[C:16]([C:18]2[S:22][C:21]3[CH:23]=[CH:24][CH:25]=[CH:26][C:20]=3[C:19]=2[Cl:27])=[O:17])=[CH:45][N:44]=1