Chloropyrazine → 3-Chloro-benzo[b]thiophene-2-carboxylic acid (2-ethoxy-5-pyrazin-2-yl-benzyl)-(4-methylamino-cyclohexyl)-amide dihydrochloride

Participants

Role	Name	HCID	Charge
Reactant	Chloropyrazine	HCID 73277	—
Reactant	3-{[[4-(BOC-methyl-amino)-cyclohexyl]-(3-chloro-benzo[b]thiophene-2-carbonyl)-amino]-methyl}-4-ethoxy-benzene boronic acid	HCID 59683494	—
Product	3-Chloro-benzo[b]thiophene-2-carboxylic acid (2-ethoxy-5-pyrazin-2-yl-benzyl)-(4-methylamino-cyclohexyl)-amide dihydrochloride	HCID 68313575	—

The title compound is prepared from boronic acid 12 (25 mg, 42 μmol) and 2-chloropyrazine (4.0 mg, 35 μmol) in accordance with Method L2.