HRID2389612

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID519898

3-Chlorobenzo[b]thiophene-2-carbonyl chloride

C9H4Cl2OS

结构：COc1ccc(-c2ccnc(C)c2)cc1CNC1CCC(N(C)C(=O)OC(C)(C)C)CC1

HCID59683623

未命名化合物

PRODUCTS

生成物

结构：CNC1CCC(N(Cc2cc(-c3ccnc(C)c3)ccc2OC)C(=O)c2sc3ccccc3c2Cl)CC1.Cl.Cl

HCID68313853

未命名化合物

收率 123.5%

PROCEDURE

实验过程

Biaryl amine 88 (250 mg, 0.57 mmol) is treated with 3-chlorobenzo-[b]thiophene-2-carbonyl chloride (157 mg, 0.68 mmol) using Method D. The resultant amide (175 mg, 0.28 mmol) isolated after chromatography is then directly deprotected using Method F to afford the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-edf558bbd027467fb73c6303a21f1f71
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08273747B2
来源说明: uspto-grants-2012_09

反应 SMILES

[CH3:1][O:2][C:3]1[CH:25]=[CH:24][C:23]([C:26]2[CH:31]=[CH:30][N:29]=[C:28]([CH3:32])[CH:27]=2)=[CH:22][C:4]=1[CH2:5][NH:6][CH:7]1[CH2:12][CH2:11][CH:10]([N:13]([CH3:21])C(=O)OC(C)(C)C)[CH2:9][CH2:8]1.[Cl:33][C:34]1[C:35]2[CH:45]=[CH:44][CH:43]=[CH:42][C:36]=2[S:37][C:38]=1[C:39](Cl)=[O:40]>>[ClH:33].[ClH:33].[CH3:1][O:2][C:3]1[CH:25]=[CH:24][C:23]([C:26]2[CH:31]=[CH:30][N:29]=[C:28]([CH3:32])[CH:27]=2)=[CH:22][C:4]=1[CH2:5][N:6]([CH:7]1[CH2:12][CH2:11][CH:10]([NH:13][CH3:21])[CH2:9][CH2:8]1)[C:39]([C:38]1[S:37][C:36]2[CH:42]=[CH:43][CH:44]=[CH:45][C:35]=2[C:34]=1[Cl:33])=[O:40]