HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(4-bromophenyl)-N-methylacetamide → tert-Butyl (4-{[4'-(acetyl-methyl-amino)-4-methoxy-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(4-bromophenyl)-N-methylacetamide | HCID 4324567 | — |
| Reactant | 3-{[4-(BOC-methyl-amino)-cyclohexylamino]-methyl}-4-methoxy-benzene boronic acid | HCID 25208191 | — |
| Product | tert-Butyl (4-{[4'-(acetyl-methyl-amino)-4-methoxy-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamate | HCID 59683468 | — |
Reaction Steps
Boronic acid 4 (650 mg, 1.04 mmol) is coupled to aryl bromide 62 (238 mg, 1.04 mmol) using Method A to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273747B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-69f107135fcb4021901b5992a5c2d419 |
| Source note | uspto-grants-2012_09 |