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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2389620Generated: October 26, 2026

N-(4-bromophenyl)-N-methylacetamide → tert-Butyl (4-{[4'-(acetyl-methyl-amino)-4-methoxy-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamate

https://huagongshe.com/reaction/2389620

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(4-bromophenyl)-N-methylacetamideHCID 4324567—
Reactant3-{[4-(BOC-methyl-amino)-cyclohexylamino]-methyl}-4-methoxy-benzene boronic acidHCID 25208191—
Producttert-Butyl (4-{[4'-(acetyl-methyl-amino)-4-methoxy-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamateHCID 59683468—

Reaction Steps

Boronic acid 4 (650 mg, 1.04 mmol) is coupled to aryl bromide 62 (238 mg, 1.04 mmol) using Method A to give the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08273747B2
Source datasetuspto-grants-2012_09
ORD IDord-69f107135fcb4021901b5992a5c2d419
Source noteuspto-grants-2012_09